The Melrose Club Golf Course is an 18-hole resort golf course in Daufuskie Island, South Carolina, built in 1987 and designed by Jack Nicklaus. It sits in the $$$$ (splurge) price range for golf in South Carolina. The course is open all year. Tee times can be booked 1 year in advance. Guests are welcome.
Details like fees and seasons change, so call the course before you head out.